引言
造血干细胞(hematopoietic stem cell, HSC)在包括人类在内的哺乳动物成年阶段发挥着核心造血作用,其通过逐级分化可以产生几乎所有血细胞类型从而建立成年个体的等级化血液系统。小鼠胚胎发育过程中,在HSC产生之前存在着独立于HSC起源的造血祖细胞,包括淋系祖细胞【1】。长久以来,研究人员普遍认为HSC在产生之后即开始负责等级血液系统的建立。随着研究深入,研究人员逐渐认识到,胚胎期的HSC对功能性血细胞的贡献相对有限,主要造血器官如胎肝中大部分造血祖细胞并非由HSC定植后逐步分化而来,而是由胚外的卵黄囊(yolk sac, YS)独立产生并迁移至此【2】,这凸显了非HSC依赖的造血在整个胚胎发育中的重要地位。然而,人类胚胎期是否同样存在独立于HSC的淋系造血活动仍未可知。此外,虽然人类卵黄囊作为已知的负责独立产生髓系、红系和巨核系的重要造血器官,其淋系潜能的研究仍处于初步阶段。
2024年7月11日,来自血液与健康全国重点实验室的刘晨助理研究员、刘兵研究员、兰雨研究员、程涛教授合作在Developmental Cell杂志在线发表了题为 Human yolk sac-derived innate lymphoid-biased multipotent progenitors emerge prior to hematopoietic stem cell formation的研究成果。该工作首次深入解析了人类HSC产生之前的淋系祖细胞发育规律,回答了其起源位点、分化偏向及迁移动力学等基础性科学问题。

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文章来源|“BioArt”
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