内容简介

本研究论文聚焦于通过选区激光熔融工艺开发一种生物型钽金属接骨板应用于骨折内固定。选区激光熔融工艺（SLM）是常用的一种应用于金属材料加工的增材制造技术。与传统机械加工技术相比，增材制造技术可以根据患者骨植入部位的解剖结构设计与打印植入体。这种植入体可以完全适配于植入部位骨组织结构和形态。钽金属作为一种亲生物金属，与骨组织具有极佳的亲和力。多孔钽可以引导骨长入，形成骨组织和接骨板一体化结构，具有长期稳定性，不需要二次手术取出；多孔钽可以降低接骨板弹性模量，从而减少应力遮挡效应，加速骨折部位组织修复再生。本论文系统研究了选区激光熔融钽金属、选区激光熔融Ti6Al4V合金以及表面具有化学气相沉积钽涂层的Ti6Al4V合金的理化性能。选区激光熔融钽金属具有良好的综合力学性能，更佳的生物相容性和促成骨相关的生物活性；同时我们还发现钽金属的免疫源性也显著低于Ti6Al4V，有助于减少植入体周围组织炎性，促进骨组织修复再生。临床试验也验证了选区激光熔融钽金属接骨板用于骨折内固定的优势与可行性。

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