Volume 2 Issue 10
封面解读
孔明
Biological target detections have long been regarded as critical concerns in early diagnosis, prevention, and therapy of diseases. Therefore, an eligible detecting tool for ready operation, sampling, and detection with high sensitivity and repeatability is highly required. We developed a novel detection platform that complexed polydiacetylene (PDA) liposomes with swellable microneedles (MNs). Thanks to thein situsampling capacity of microneedles and the unique optical properties of PDA liposomes that change in response to external stimuli, we integrated target sampling and detection in one platform (PDA/MNs). PDA/MNs exhibited higher sensitivity than their counterparts in the liquid phase, reflected by the significantly lower limit of detection (LOD) towards lead ion (Pb2+) and sialic acid (SA). The results suggest that such PDA/MNs are validated to provide a label-free, stable, sensitive, and convenient tool in an all-in-one manner for physiologic target detection.
目 录
导 读
1. Kha-Ti Lim: Mother of ten thousand infants
通讯作者：朱兰
Dr. Kha-Ti Lim earned the title of “Mother of Ten Thousand Infants” by personally delivering more than 50,000 newborns. She conducted pioneering research on subjects including fetal intrauterine respiration, female pelvic disorders, and gynecological tumors. Dr. Lim has been recognized as a founding figure of modern obstetrics and gynecology in China.
引用：
Liu X, Huang R, Zhu L. Kha-Ti Lim: Mother of ten thousand infants. hLife 2024; 2: 493–495.
2. Regulatory functions and mechanisms of human microbiota in infectious diseases
hLife Review | 人体微生物群在感染性疾病中的调控功能与作用机制
通讯作者：张令强, 刘翠华, 柴琪瑶
文章系统综述了微生物群、人类宿主和病原体三维调控网络在感染性疾病中的调控功能和作用机制，以及外界环境因素对此过程的动态影响，并深入探讨了基于人体微生物群开发感染性疾病诊断、预防和治疗新手段的新思路与新策略。
引用：
Fang Y, Lei Z, Zhang L, et al. Regulatory functions and mechanisms of human microbiota in infectious diseases. hLife2024; 2: 496–513.
3. Construction and investigation of all-in-one microneedles complexed with functionalized polydiacetylene liposomes for improvedin situdetection sensitivity
hLife Article | 功能化聚二乙炔脂质体-微针复合体的制备及其在生理靶标物原位采样与高灵敏检测一体化中的应用
通讯作者：Jumin Lee,孔明
基于聚二乙炔（Polydiacetylene，PDA）脂质体独特的触变光学特性，结合溶胀型微针原位取样技术，研发了一种集采样和检测一体化，兼具非标记、稳定、灵敏和便捷性的生物标志物检测技术。
引用：
Wang J, Li W, Chen Y, et al. Construction and investigation of all-in-one microneedles complexed with functionalized polydiacetyleneliposomes for improvedin situdetection sensitivity.hLife2024; 2: 514–526.
4. Structural insights into the distinct protective mechanisms of human antibodies targeting ZIKV NS1
hLife | 揭秘寨卡病毒NS1抗体的不同保护机制：表位差异如何影响防御
通讯作者：赵卫, 庾蕾, 胡红丽
该研究结合结构和生化实验揭示了两组靶向寨卡病毒（ZIKV）NS1蛋白不同表位抗体的差异保护机制。
引用：
Pan Q, Xing X, Yu J, et al. Structural insights into the distinct protective mechanisms of human antibodies targeting ZIKV NS1.hLife2024; 2: 527–541.
5. Advancements for microbiome research in human health and disease: From composition to functionality
通讯作者：秦楠
The 10th International Human Microbiome Consortium (IHMC) congress focused on important topics such as “The interaction of the humanholobiont with other bionts” “Environmental factors influencing the human holobiont” “Oncobiome: A network introducing gut microbiota into oncology” and “Microbiome and cancer development”.
引用：
Qin N, Ehrlich SD. Advancements for microbiome research in human health and disease: From composition to functionality.hLife2024; 2: 542–545.
